
Jim Keller joined Tenstorrent as CTO in December 2020. Though later it was reported that he left over a dispute on whether the company should outsource more of its production. He resigned from Intel June 2020 officially citing personal reasons. In April 2018, Keller joined Intel, where he served as Senior Vice President. as Vice President of Autopilot Hardware Engineering. In January 2016, Keller joined Tesla, Inc. On September 18, 2015, Keller departed from AMD to pursue other opportunities, ending his three-year employment at AMD. After years of being unable to compete with Intel in the high-end CPU market, the new generation of Zen processors has restored AMD's ability to do just that. In August 2012, Jim Keller returned to AMD, where his primary task was to lead development of new generation of x86-64 and ARM microarchitectures called Zen and K12. These processors were used in several Apple products, including iPhone 4, 4S, iPad and iPad 2.

The new team worked to design the Apple A4 and A5 system-on-a-chip mobile processors. Semi was acquired by Apple shortly afterwards, reuniting Keller with his prior team from P.A. Semi, a company specializing in low-power mobile processors. In 2004 he moved to serve as the Vice President of Engineering at P.A. In November 2000, SiByte was acquired by Broadcom, where he continued as chief architect until 2004.

In 1999, he left AMD to work at SiByte to design MIPS-based processors for 1 Gbit/s network interfaces and other devices. In 1998 he moved to AMD, where he worked to launch the AMD Athlon (K7) processor and was the lead architect of the AMD K8 microarchitecture, which also included designing the x86-64 instruction set and HyperTransport interconnect mainly used for multiprocessor communications. Prior to DEC, he had worked at Harris Corporation on microprocessor boards.

Jim Keller joined DEC in 1982, and worked there until 1998, where he was involved in designing a number of processors, including the VAX 8800, the Alpha 21164 and the Alpha 21264 processors. in Electrical Engineering from Pennsylvania State University which he earned in 1980.
